Fluorosis disease is a public health problem caused by consumption of fluoride (F ̄) through water, food and use of F ̄ containing dental products. Long term treatment with F ̄ containing drugs and exposure to industrial emission has severely affected the community in India.1,2 The first report on patients of Fluorosis from India was reported in 1937.3 Amarjeet Singh and Jolly had investigated patients and revealed their clinical, biochemical and radiological characteristics in great detail.4,5 What is most striking is that the initial reports by Indian medical professionals were focussing on skeletal and dental Fluorosis only. The concept was based on the fact that electronegative and highly reactive element fluorine reacted with the positively charged cations i.e. Ca++, abundantly found in the bones and teeth, resulting in skeletal and dental fluorosis entities. The concept that a chemical poison F ̄ can bind with Ca++ or other positively charged ions in tissues in the body other than bone and teeth was seldom explored.