Fluoride Levels of Human Plasma and Breast Milk by Yağmur Şenera DDS PhD, Gül Tosuna DDS PhD , Firdevs Kahvecioğlub DDS PhD, Alparslan Gökalpc DDS PhD, Hasan Koçd , MD

The aim of this study was to determine the fluoride levels in breast milk and plasma oflactating mothers who regularly consumed drinking water with low levels of fluoride.Methods: One hundred twenty five healthy mothers aged between 20-30 years old who had givenbirth within 5-7 days were included in the study. Besides being otherwise healthy, the primary selectioncriteria stipulated the absence of fluoride supplement consumption one month before delivery. Approximately5 ml breast milk and 5 ml blood samples were obtained from each participating mother at ahospital setting, where the mothers were scheduled for a regular hospital diet. The blood samples werecentrifuged in fluoride-free heparinized polyethylene tubes and stored at -18oC until measurementswere made. Breast milk samples were directly refrigerated as with blood samples until measurements.The fluoride concentrations of milk and blood samples were assessed using an ion-selective fluorideelectrode combined with an ion analyzer.Results: The fluoride levels of the plasma and breast milk samples were measured as 0.017±0.011ppm and 0.006±0.002 ppm, respectively. The fluoride concentration of plasma was significantly higherthan that of breast milk (P<.01). Correlation analysis revealed a significant relation between the groups(P<.01).Conclusion: A limited level of fluoride transmission from plasma to breast milk was detected. Nevertheless,a significant correlation between the fluoride concentrations of breast milk and plasma wasevident. (Eur J Dent 2007;1:21-24)


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612944/pdf/dent1_p021.pdf