Determination of Inorganic Fluoride in Blood with a Fluoride Ion-Selective Electrode by Erik Klesa

Inorganic fluoride in whole blood, serum, or plasma has been determined with a fluoride ion-selective electrode by adding the 0.5- to 2.0-mL sample to 20 mL of water containing a buffer and fluoride, 25 µ g/L. The fluoride concentration in the sample is calculated from the resulting cell potential differ- ence recorded after equilibrating for 10 mm. This novel method has the advantages of simplicity, accuracy, and high precision, standard deviations for 5 to 7 replicate determinations of fluoride ranging from ± 1.7 to ±2.4 µ g/L. For whole blood from donors living In an area with fluorinated drinking water, the F concentration was 20 to 60 µ g/L.

Link : http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.575.9365&rep=rep1&type=pdf