In Vivo & In Vitro Anti-Inflammatory Activity Of The Methanolic Extract And Isolated Compound From The Leaves Of Cassia Tora L. (Leguminosae/Caesalpinaceae) By Amalesh Samanta , Gouranga Das , Soma Ghosh, Durbadal Ojha

The methanolic extract of leaves of Cassia tora L, family Leguminosae/Caesalpinaceae was showed anti-inflammatory activity by in vivo (carrageenan & dextran induced paw edema, exudative  inflammation and cotton pellet granuloma) methods and in vitro (cyclooxygenase inhibition) model at different doses. Methanolic extract produced significant anti-inflammatory activity as compared to indomethacin. Furthermore, the bio activity guided investigation showed the presence of quercetin 3-O-rhamnoside (CT-1) as major chemical constituent, which was identified by spectroscopic  analysis and it shown significant anti- inflammatory activity. The study confirmed that flavonoid glycoside of C. tora L are responsible for anti-inflammatory activity.