Tuesday, 7 October 2014

Excessive Fluoride Delineating Biochemical Changes in Seminal Plasma: A Case Control Clinical Study By Dushyant Singh Chauhan, Sandeep Tripathi, Vivek Pratap Singh, Surabhi Tomar, Shobha Tomar, Mukesh Tiwari, Abbas Ali Mahdi

Fluorosis has become an endemic problem in India and  worldwide. Significant interest has occurred on potential decline in the semen quality due to contamination of fluoride in drinking water. The aim of the present study was to investigate the possible impact of fluoride exposure on the semen quality. In the present study, 150 subjects (age 25-40) were recruited from the high fluoride region of Rajasthan, India, where fluoride content in ground water was more than 2.0 ppm. The age matched controls were selected from the area where fluoride level was less than 1.5 ppm. The total protein, fructose, lipid, phospholipids and cholesterol levels were estimated in seminal plasma and correlates with the semen volume, liquefaction time, viability and motility followed by the estimation of fluoride concentration in serum and urine. A significant (p<0.05) reduction was observed in fructose, protein, lipids and phospholipids while the concentration of cholesterol was raised in subjects as compared to controls. Diminished semen quality in term of Volume, Liquefaction time, Viability and motility were noticed along with the elevated levels of fluoride in serum and urine. On the basis of results it may conclude that high exposure of fluoride through drinking water may be associated with reduced semen quality in population of endemic fluorosis areas.

Link : http://euacademic.org/UploadArticle/994.pdf

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