Oral Calcium Supplementation Reverses The Biochemical Pattern Of Parathyroid Hormone Resistance In Underprivileged Indian Toddlers By A Khadilkar, M Z Mughal, N Hanumante

Background: Toddlers in Pune, India, accustomed to low dietary calcium intake but vitamin D replete have low serum ionised calcium and inappropriately raised serum inorganic phosphorus concentrations together with elevated serum parathyroid hormone (PTH) concentrations. We hypothesised that dietary calcium deficiency leads to end organ resistance to PTH, thus resulting in
mild hypocalcaemia and hyperphosphataemia, and that this would be reversed by oral calcium supplementation.